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口腔癌诊断的新进展:通往早期发现之路

2012-02-07 16:44:17 来源: 作者: 人气:0 评论:0
尽管多种恶性肿瘤的治疗取得了显著进展,但口腔鳞癌患者的预后依然欠佳。早期诊断与治疗仍然是改善患者生存率的关键。由于切取活检具有创伤性和潜在的并发症,只能作为临床上高度怀疑的恶性病变的检查手段,而不适于大多数临床上不怀疑为恶性的口腔病变。另外,切取活检对于组织学上诊断为异常增生的病变,在经验不同的病理科医生之间,存在显著差异。因此,迫切需要开发针对口腔异常增生和恶性病变的实用、无创、门诊上易于操作的诊断工具。早期病变的诊断性试验包括刷拭活检、甲苯氨蓝染色、自体荧光、唾液蛋白质组学、DNA分析,生物标志物和光谱学分析等。

The prognosis for patients with oral squamous cell carcinoma remains poor in spite of advances in therapy of many other malignancies. Early diagnosis and treatment remains the key to improved patient survival. Because the scalpel biopsy for diagnosis is invasive and has potential morbidity, it is reserved for evaluating highly suspicious lesions and not for the majority of oral lesions which are clinically not suspicious. Furthermore, scalpel biopsy has significant interobserver and intraobserver variability in the histologic diagnosis of dysplasia. There is an urgent need to devise critical diagnostic tools for early detection of oral dysplasia and malignancy that are practical, noninvasive and can be easily performed in an out-patient set-up. Diagnostic tests for early detection include brush biopsy, toluidine blue staining, autofluorescence, salivary proteomics, DNA analysis, biomarkers and spectroscopy.

Exciting new advances in oral cancer diagnosis.pdf

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